Adsorption of drugs on silica aerogels

被引：179

作者：

Smirnova, I ^{[1
]}

Mamic, J ^{[1
]}

Arlt, W ^{[1
]}

机构：

[1] Tech Univ Berlin, Fachgebiet Thermodynam & Therm Verfahrenstechn, D-10623 Berlin, Germany

来源：

LANGMUIR | 2003年 / 19卷 / 20期

关键词：

D O I：

10.1021/la0345587

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The adsorption of drugs on silica aerogels has been investigated. Adsorption takes place from the solution of a corresponding drug in supercritical CO2. Adsorption isotherms were measured for one model substance, naphthalene, and two drugs, ketoprofen and miconazole, at 40 C. It has been shown that both drugs exhibit a high affinity to silica aerogel what gives a possibility to use aerogels as a drug carrier in aerogel-drug formulations. The knowledge of the adsorption isotherm allows to control the loading of aerogels with drugs in such formulations. Both hydrophilic and hydrophobic aerogels can be used as a carrier. The influence of the hydrophobicity of the carrier material on the adsorption process is discussed.

引用

页码：8521 / 8525

页数：5

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