Design and synthesis of a pyridone-based phosphotyrosine mimetic

被引：11

作者：

Fu, JM ^{[1
]}

Castelhano, AL ^{[1
]}

机构：

[1] Cadus Pharmaceut Corp, Tarrytown, NY 10591 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(98)00503-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (p;Tyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of beta-iodoalanine with phosphonomethyl 4-pyridone triflate. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2813 / 2816

页数：4

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