The preparation of enantiomerically pure cyclopropylalanine

被引：19

作者：

Boaz, NW ^{[1
]}

Debenham, SD ^{[1
]}

Large, SE ^{[1
]}

Moore, MK ^{[1
]}

机构：

[1] Eastman Chem Co, Res Labs, Kingsport, TN 37662 USA

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 22期

关键词：

D O I：

10.1016/j.tetasy.2003.07.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Single enantiomer cyclopropylalanine (>99.9% ee) and various derivatives were prepared using an asymmetric hydrogenation approach with a rhodium catalyst based on the methyl BoPhox(TM) ligand. N-Boc cyclopropylalanine benzyl ester was the preferred derivative, as this material is ripe for further selective reaction and can be recrystallized to >99.5%, enantiomeric excess. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：3575 / 3580

页数：6

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