Growth Inhibition of Various Human Cancer Cell Lines by Imperatorin and Limonin from Poncirus Trifoliata Rafin. Seeds

被引：76

作者：

Rahman, Atiqur ^{[1
]}

Siddiqui, Shah Alam ^{[1
]}

Jakhar, Rekha ^{[2
]}

Kang, Sun Chul ^{[2
]}

机构：

[1] Islamic Univ, Dept Appl Chem & Chem Technol, Kushtia 7003, Bangladesh

[2] Daegu Univ, Dept Biotechnol, Kyongsan 712714, Kyoungbook, South Korea

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2015年 / 15卷 / 02期

关键词：

Anticancer activity; imperatorin; limonin; Poncirus trifoliata rafin; colon cancer; liver cancer; CITRUS LIMONOIDS; APOPTOSIS; COUMARINS; FRUITS; AGENTS; PLANTS; BAX;

D O I：

10.2174/1871520614666140922122358

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We examined the anticancer effects of limonin and imperatorin on various human cancer cells by MTT assay, and the results showed that imperatorin inhibited the cell growth of SNU 449 (liver cancer) and HCT-15 (colon cancer) cells in a dose-dependent manner, while limonin had less effect. Exposure of different concentrations of limonin and imperatorin caused morphological changes in cancer cells, but not in normal dermal fibroblast cells. Limonin and imperatorin induced apoptotic cell death concurrent to cell cycle arrest in SNU 449 and HCT-15 cells. Limonin and imperatorin up regulated proapoptotic protein Bax expression and down regulated anti-apoptotic protein Bcl-2 expression in a dose-dependent manner in HCT-15 and SNU 449 cells. In conclusion, our data demonstrate that limonin and imperatorin have anticancer potential which is associated with promoting cell apoptosis through expression of apoptosis-related proteins.

引用

页码：236 / 241

页数：6

共 31 条

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