Association study of human leukocyte antigen-DRB1 alleles with rheumatoid arthritis in Algerian patients

被引：8

作者：

Djidjik, Reda ^{[1
]}

Allam, Ines ^{[1
]}

Douaoui, Sanaa ^{[1
]}

Meddour, Yanis ^{[2
]}

Cherguelaine, Khaled ^{[1
]}

Tahiat, Azzedine ^{[1
]}

Raaf, Nabil ^{[1
]}

Abdessemed, Amina ^{[3
]}

Khaldoun, Naouel ^{[3
]}

Bahaz, Naima ^{[4
]}

Chaib, Samia ^{[2
]}

Ladjouze-Rezig, Aicha ^{[3
]}

Ghaffor, Mohamed ^{[1
]}

机构：

[1] CHU Beni Messous, Dept Immunol, Algiers, Algeria

[2] Cent Hosp Army, Dept Immunol, Algiers, Algeria

[3] EPH Benaknoun, Dept Rheumatol, Algiers, Algeria

[4] CHU Beni Messous, Dept Rheumatol, Algiers, Algeria

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2017年 / 20卷 / 12期

关键词：

anti-cyclic peptides antibodies; HLA-DRB1; alleles; rheumatoid arthritis; rheumatoid factor; CYCLIC CITRULLINATED PEPTIDE; HLA-DRB1 SHARED EPITOPE; GENETIC CONTRIBUTION; HUNGARIAN PATIENTS; ANTIBODY; HLA; POPULATION; PROTEINS;

D O I：

10.1111/1756-185X.12272

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

IntroductionRheumatoid arthritis (RA) is a chronic, systemic, inflammatory and multifactorial disease. Genetic predisposition seems to play an important role. The aim of this study is to explore the relationship between human leukocyte antigen (HLA)-DRB1 alleles and susceptibility, clinical and biological features of RA in an Algerian patient population. MethodsUsing polymerase chain reaction - sequence specific primers (SSP), 134 RA patients and 132 healthy controls were genotyped for HLA-DRB1 and HLA-DRB1*04 subtypes. ResultsHLA-DRB1*04 was found to have increased frequency in the RA group compared to controls (P<0.001, OR=3.14), and was associated with anti-citrullinated protein antibodies positivity (ACPA) (P=0.01, OR=2.35). In contrast, HLA-DRB1*07 was found to have a decreased frequency in patients compared to controls (P=0.003, OR=0.44) and significant decrease was observed in patients with the rheumatoid factor (RF) positivity subgroup (P=0.009, OR=0.29). HLA-DRB1*04:05 was associated with RA (P=0.005, OR=3.41), whereas, HLA-DRB1*04:02 showed a protective effect against RA (P=0.003, OR=0.20). ConclusionsHLA-DRB1*04 was associated with increased risk for RA and ACPA positivity, while HLA-DRB1*07 was associated with reduced risk for RA and RF synthesis in Algerian patients.

引用

页码：1993 / 1997

页数：5

共 32 条

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