Clinicopathological significance of peritumoral lymphatic vessel density in gastric carcinoma

被引：47

作者：

Gao, Peng ^{[1
]}

Zhou, Geng-Yin ^{[1
]}

Zhang, Qing-Hui ^{[1
]}

Xiang, Lei ^{[1
]}

Zhang, Shun-Li

Li, Chao ^{[2
]}

Sun, Yan-Lin ^{[1
]}

机构：

[1] Shandong Univ, Dept Pathol, Sch Med, Jinan 250012, Peoples R China

[2] Med Coll Ningxia Hui Autonomous Reg, Dept Surg, Yinchuan 750004, Peoples R China

来源：

CANCER LETTERS | 2008年 / 263卷 / 02期

基金：

中国国家自然科学基金;

关键词：

gastric carcinoma; lymphatic vessel density (LVD); lymphangiogenesis; LYVE-1; prognosis;

D O I：

10.1016/j.canlet.2008.01.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Lymphangiogenesis has recently been considered important for spread of malignant tumors. in the present study, lymphatic vessel density (LVD) including peritumoral LVD (P-LVD) and intratumoral LVD (I-LVD) was determined, respectively, by immunohistochemical staining with the antibody to LYVE-1 in 63 cases of early gastric carcinoma and 105 cases of advanced gastric carcinoma. The aim of the study is to investigate whether or not increased LVD Could be a risk factor for nodal metastasis and survival. We Conclude that increased P-LVD, but not I-LVD, could serve as an independent risk factor for nodal metastasis, recurrence and overall survival in gastric carcinoma. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：223 / 230

页数：8

共 18 条

[1]

LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan [J].