Differentially expressed genes in hypertensive rats developing cerebral ischemia

被引：7

作者：

Zhu, ZM ^{[1
]}

Zhao, B

Wang, XM

Zhu, SJ

Zhang, Q

Xu, YY

Hui, RY

Tepel, MT

机构：

[1] Third Mil Med Univ, Daping Hosp, Dept Hypertens & Endocrinol, Chongqing 400042, Peoples R China

[2] Chinese Acad Med Sci, Mol Med Ctr Cardiovasc Dis, Fu Wai Hosp, Beijing, Peoples R China

[3] Free Univ Berlin, Med Klin 4, Berlin, Germany

来源：

LIFE SCIENCES | 2004年 / 74卷 / 15期

基金：

中国国家自然科学基金;

关键词：

hypertension; stroke; gene expression;

D O I：

10.1016/j.lfs.2003.08.038

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The molecular events occuring after cerebral ischemia in hypertension may include de novo expression of numerous genes. Receptor genes are predominantely involved in the process of cell death, neuroprotection and reconstruction after ischemic injury. Ischemic stroke was observed in the non-genetic, non-surgical model of hypertension, the cold-induced hypertensive rat. In hypertensive rats suppression subtractive hybridization analysis was used to identify differentially expressed receptor genes in stroke-tissue compared to normal rat brain. We found 76 genes predominantely expressed in hypertensive rat stroke-tissue. These predominantely expressed genes included genes involved in energy metabolism, signal transduction/cell regulation, and replication/transcription/translation. For example, the T3 receptor alpha was predominantely expressed in stroke-tissue, indicating that regeneration of nerves in stroke tissue may be facilitated by increased T3 receptor alpha expression. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1899 / 1909

页数：11

共 39 条

[1]

Abe K, 1998, CELL MOL NEUROBIOL, V18, P709, DOI 10.1023/A:1020230220971

[2]

ADAMS MD, 1995, NATURE, V377, P3

[3] RATE-RELATED ELECTROPHYSIOLOGIC EFFECTS OF LONG-TERM ADMINISTRATION OF AMIODARONE ON CANINE VENTRICULAR MYOCARDIUM INVIVO [J].

ANDERSON, KP ;

WALKER, R ;

DUSTMAN, T ;

LUX, RL ;

ERSHLER, PR ;

KATES, RE ;

URIE, PM .

CIRCULATION, 1989, 79 (04) :948-958

[4] Ischemic preconditioning and brain tolerance - Temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression [J].

Barone, FC ;

White, RF ;

Spera, PA ;

Ellison, J ;

Currie, RW ;

Wang, XK ;

Feuerstein, GZ .

STROKE, 1998, 29 (09) :1937-1950

[5]

BEEREN HC, 2003, ENDOCRINOLOGY, V144, P552

[6] Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors [J].

Calzà, L ;

Forrest, D ;

Vennström, B ;

Hökfelt, T .

NEUROSCIENCE, 2000, 101 (04) :1001-1012

[7] Thyroid hormone and central nervous system development [J].

Chan, S ;

Kilby, MD .

JOURNAL OF ENDOCRINOLOGY, 2000, 165 (01) :1-8

[8]

Chim SS, 2000, J CELL BIOCHEM, V80, P24

[9]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[10] Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries [J].

Diatchenko, L ;

Lau, YFC ;

Campbell, AP ;

Chenchik, A ;

Moqadam, F ;

Huang, B ;

Lukyanov, S ;

Lukyanov, K ;

Gurskaya, N ;

Sverdlov, ED ;

Siebert, PD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :6025-6030

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