A 96-week comparison of lopinavir-ritonavir combination therapy followed by lopinavir-ritonavir monotherapy versus efavirenz combination therapy

被引：92

作者：

Cameron, D. William ^{[1
]}

da Silva, Barbara A. ^{[3
]}

Arribas, Jose R. ^{[6
]}

Myers, Robert A. ^{[4
]}

Bellos, Nicholaos C. ^{[5
]}

Gilmore, Norbert ^{[2
]}

King, Martin S. ^{[3
]}

Bernstein, Barry M. ^{[3
]}

Brun, Scott C. ^{[3
]}

Hanna, George J. ^{[3
]}

机构：

[1] Univ Ottawa, Ottawa Hosp, Div Infect Dis, Ottawa, ON, Canada

[2] McGill Univ, Ctr Hlth, Montreal, PQ, Canada

[3] Abbott Labs, Abbott Pk, IL 60064 USA

[4] Body Posit Inc, Phoenix, AZ USA

[5] SW Infect Dis Associates, Dallas, TX USA

[6] Hosp La Paz, Madrid, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 02期

关键词：

D O I：

10.1086/589622

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antiretroviral-naive HIV-1-infected volunteers received zidovudine/lamivudine plus either lopinavir/ritonavir (n = 104) or efavirenz (n = 51). Lopinavir/ritonavir-treated subjects demonstrating 3 consecutive monthly HIV-1 RNA levels <50 copies/mL started lopinavir/ritonavir monotherapy. In previous-failure = failure analysis, 48% (lopinavir/ritonavir) and 61% (efavirenz) maintained HIV-1 RNA at <50 copies/mL through week 96, (P = .17; 95% confidence interval [CI] for the difference, -29% to 4%); in noncompletion = failure analysis, 60% (lopinavir/ritonavir) and 63% (efavirenz) maintained HIV-1 RNA at < 50 copies/ mL at week 96 (P = .73; 95% CI for the difference, -19% to 13%). Significant sparing of peripheral lipoatrophy was noted in the lopinavir/ritonavir simplification strategy. This study has provided important information for future studies using treatment simplified to lopinavir/ritonavir monotherapy.

引用

页码：234 / 240

页数：7

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