Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease

被引：94

作者：

Calabresi, Laura ^{[1
]}

Simonelli, Sara ^{[1
]}

Gomaraschi, Monica ^{[1
]}

Franceschini, Guido ^{[1
]}

机构：

[1] Univ Milan, Dept Pharmacol Sci, Ctr E Grossi Paoletti, I-20133 Milan, Italy

来源：

ATHEROSCLEROSIS | 2012年 / 222卷 / 02期

关键词：

LCAT; HDL; Cardiovascular disease; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; HIGH-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; ISCHEMIC-HEART-DISEASE; PLASMA LECITHIN; LCAT DEFICIENCY; FAMILIAL LECITHIN; VASCULAR-DISEASE; PRE-BETA(1) HDL; FATTY-ACID;

D O I：

10.1016/j.atherosclerosis.2011.11.034

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The lecithin: cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the genetic and biochemical features of LCAT deficiency, highlighting the absence of enhanced preclinical atherosclerosis in carriers, despite the remarkably low HDL cholesterol. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：299 / 306

页数：8

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