In normal postmenopausal women physiologic estrogen replacement therapy fails to improve exercise tolerance: A randomized, double-blind, placebo-controlled, crossover trial

被引:15
作者
Snabes, MC
Herd, JA
Schuyler, N
Dunn, K
Spence, DW
Young, RL
机构
[1] BAYLOR COLL MED, DEPT OBSTET & GYNECOL, DIV REPROD ENDOCRINOL, HOUSTON, TX 77030 USA
[2] BAYLOR COLL MED, DEPT MED, DIV ATHEROSCLEROSIS, HOUSTON, TX 77030 USA
[3] BAYLOR COLL MED, DEPT MED, DIV DESIGN & ANAL, HOUSTON, TX 77030 USA
[4] RICE UNIV, HOUSTON, TX 77251 USA
关键词
postmenopausal; treadmill exercise; estrogen replacement; women;
D O I
10.1016/S0002-9378(96)70259-4
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Our purpose was to test whether estrogen replacement therapy could increase exercise tolerance in postmenopausal women. STUDY DESIGN: A randomized, double-blind, placebo-controlled, crossover study in 31 healthy postmenopausal women who received 12 weeks of physiologic estrogen replacement therapy (micronized estradiol, 2 mg/day) and were evaluated with modified Balke exercise treadmill tests. RESULTS: Serum estradiol levels increased significantly during replacement therapy in this cohort of female volunteers with a mean age of 59 years, and resting heart rate was lower in women receiving estrogen replacement (p < 0.05). However, neither the heart rate nor the blood pressure responses to exercise was different, nor was the total exercise time, rate of oxygen uptake, or maximal oxygen uptake increased after estradiol treatment. Similarly, ventilatory parameters were unaffected by estradiol. The slope of the respiratory exchange ratio was slightly but significantly different (p < 0.05) while volunteers received estrogen replacement therapy. CONCLUSION: Estrogen replacement therapy, which achieves serum estradiol concentrations in the physiologic range for 12 weeks, fails to increase exercise tolerance or improve cardiovascular response to exercise in postmenopausal women.
引用
收藏
页码:110 / 114
页数:5
相关论文
共 17 条
  • [1] ESTROGENS, ARTERIAL STATUS, AND POSTMENOPAUSAL WOMEN
    BOURNE, T
    HILLARD, TC
    WHITEHEAD, MI
    CROOK, D
    CAMPBELL, S
    [J]. LANCET, 1990, 335 (8703) : 1470 - 1471
  • [2] CASTELLI WP, 1988, AM J OBSTET GYNECOL, V158, P1553, DOI 10.1016/0002-9378(88)90189-5
  • [3] ACUTE VASCULAR EFFECTS OF ESTROGEN IN POSTMENOPAUSAL WOMEN
    GILLIGAN, DM
    BADAR, DM
    PANZA, JA
    QUYYUMI, AA
    CANNON, RO
    [J]. CIRCULATION, 1994, 90 (02) : 786 - 791
  • [4] 2-PERIOD CHANGE-OVER DESIGN AND ITS USE IN CLINICAL TRIALS
    GRIZZLE, JE
    [J]. BIOMETRICS, 1965, 21 (02) : 467 - &
  • [5] CARDIOVASCULAR-RESPONSES OF 70-YEAR-OLD TO 79-YEAR-OLD MEN AND WOMEN TO EXERCISE TRAINING
    HAGBERG, JM
    GRAVES, JE
    LIMACHER, M
    WOODS, DR
    LEGGETT, SH
    CONONIE, C
    GRUBER, JJ
    POLLOCK, ML
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (06) : 2589 - 2594
  • [6] ENDOTHELIUM-INDEPENDENT RELAXATION OF RABBIT CORONARY-ARTERY BY 17-BETA-ESTRADIOL INVITRO
    JIANG, CW
    SARREL, PM
    LINDSAY, DC
    POOLEWILSON, PA
    COLLINS, P
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (04) : 1033 - 1037
  • [7] THE ANALYSIS OF DATA FROM 2X2 CROSSOVER TRIALS WITH BASELINE MEASUREMENTS
    KENWARD, MG
    JONES, B
    [J]. STATISTICS IN MEDICINE, 1987, 6 (08) : 911 - 926
  • [8] ESTROGEN IMPROVES ENDOTHELIUM-DEPENDENT, FLOW-MEDIATED VASODILATION IN POSTMENOPAUSAL WOMEN
    LIEBERMAN, EH
    GERHARD, MD
    UEHATA, A
    WALSH, BW
    SELWYN, AP
    GANZ, P
    YEUNG, AC
    CREAGER, MA
    [J]. ANNALS OF INTERNAL MEDICINE, 1994, 121 (12) : 936 - 941
  • [9] LINDHEIM SR, 1994, OBSTET GYNECOL, V83, P167
  • [10] LOCAL AND SYSTEMIC ESTRADIOL-17-BETA - EFFECTS ON UTERINE AND SYSTEMIC VASODILATION
    MAGNESS, RR
    ROSENFELD, CR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04): : E536 - E542