Recent advances in the genetics of Alzheimer's disease

被引:29
作者
Levy-Lahad, E
Tsuang, D
Bird, TD
机构
[1] Shaare Zedek Med Ctr, Dept Med, IL-91000 Jerusalem, Israel
[2] VA Puget Sound Hlth Care Syst, MIRECC 116, Seattle, WA 98108 USA
[3] VA Puget Sound Hlth Care Syst, GRECC, Seattle, WA 98108 USA
[4] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA
[5] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[6] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
[7] Univ Washington, Sch Med, Dept Epidemiol, Seattle, WA 98195 USA
关键词
D O I
10.1177/089198879801100202
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Alzheimer's disease (AD) is a neurodegenerative disorder that is the most common cause of dementia in the elderly. It is a clinical-pathologic entity characterized by progressive dementia associated with the neuropathologic hallmarks of A beta amyloid plaques, neurofibrillary tangles (NFTs), neuronal loss, and amyloid angiopathy. Three "causative" AD genes (i.e., genes in which a mutation is sufficient to result in clinical AD) for early-onset familial Alzheimer's disease (FAD) and one "susceptibility" gene that affects risk and age of onset of AD in familial and sporadic late-onset AD have been identified. The three causative genes are the amyloid precursor protein (APP gene) on chromosome 21, the presenilin-1 gene on chromosome 14, and the presenilin-2 gene on chromosome 1, The susceptibility gene is the apolipoprotein E (APOE) gene on chromosome 19. Investigations of the normal and aberrant function of these genes will provide insights into the mechanisms underlying AD and will suggest new strategies for therapeutic intervention.
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页码:42 / 54
页数:13
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