Hematopoietic stem cell transplantation: Bone marrow vs. mobilized peripheral blood

被引：23

作者：

Arai, S ^{[1
]}

Klingermann, HG ^{[1
]}

机构：

[1] Rush Presbyterian St Lukes Med Ctr, Sect Bone Marrow Transplant & Cell Therapy, Chicago, IL 60012 USA

来源：

ARCHIVES OF MEDICAL RESEARCH | 2003年 / 34卷 / 06期

关键词：

bone marrow; peripheral blood; stem cell transplantation;

D O I：

10.1016/j.arcmed.2003.07.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Peripheral blood stem cells have largely replaced bone marrow as the source of cells in autologous transplantation because of more rapid neutrophil and platelet recovery and faster immune reconstitution. Allogeneic peripheral blood stem cells similarly lead to faster hematologic recovery: however, their effects on graft-vs.-host disease, relapse, survival, and immune reconstitution have been less certain. Eight randomized trials have been published to date comparing the clinical outcomes of allogeneic-related donor bone marrow transplantation (BMT) vs. PBSCT and will be reviewed. In addition, comparisons between the two stem cell sources in unrelated donor transplantation and the increasingly utilized nonmyeloablative transplantation will be discussed. (C) 2004 IMSS. Published by Elsevier Inc.

引用

页码：545 / 553

页数：9

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