Magnetization transfer and diffusion tensor MRI show gray matter damage in neuromyelitis optica

被引：109

作者：

Rocca, MA

Agosta, F

Mezzapesa, DM

Martinelli, V

Salvi, F

Ghezzi, A

Bergamaschi, R

Comi, G

Filippi, M

机构：

[1] San Raffaele Sci Inst, Dept Neurosci, Neuroimaging Res Unit, I-20132 Milan, Italy

[2] San Raffaele Sci Inst, Dept Neurol, I-20132 Milan, Italy

[3] Univ Milan, Osped San Raffaele, I-20132 Milan, Italy

[4] Univ Bologna, Osped Bellaria, Dept Clin Neurol, I-40126 Bologna, Italy

[5] Osped Gallarate, Multiple Sclerosis Ctr, Gallarate, Italy

[6] Ist Mondino, Dept Neurol, Pavia, Italy

来源：

NEUROLOGY | 2004年 / 62卷 / 03期

关键词：

D O I：

10.1212/01.WNL.0000106946.08741.41

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using magnetization transfer (MT) and diffusion tensor (DT) MRI, the authors assessed the extent of tissue damage of the brain normal-appearing white and gray matter (NAGM) in patients with neuromyelitis optica (NMO). Compared to healthy controls, patients with NMO showed reduced MT ratio and increased mean diffusivity of the NAGM. This challenges the classic notion of a sparing of the brain tissue in the course of NMO.

引用

页码：476 / 478

页数：3

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