Serotonin syndrome associated with nefazodone and paroxetine

被引：32

作者：

John, L ^{[1
]}

Perreault, MM ^{[1
]}

Tao, T ^{[1
]}

Blew, PG ^{[1
]}

机构：

[1] OTTAWA GEN HOSP,DEPT PHARM,ICU,OTTAWA,ON K1H 8L6,CANADA

来源：

ANNALS OF EMERGENCY MEDICINE | 1997年 / 29卷 / 02期

关键词：

D O I：

10.1016/S0196-0644(97)70283-X

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A 51-year-old woman was brought to the emergency department unresponsive, hyponatremic, and diaphoretic, with muscle rigidity. Her condition improved dramatically after supportive treatment and dantrolene. The patient had received nefazodone for 6 months, but the drug had been discontinued 2 days before admission after a tapering period. One day before admission, paroxetine 20 mg/day was started. A repeat challenge with paroxetine 7 days after discontinuation of nefazodone did not result in recurrence of the patient's symptoms. We believe this to be the first report of serotonin syndrome associated with nefazodone and paroxetine.

引用

页码：287 / 289

页数：3

共 17 条

[1]

BERL T, 1992, RENAL ELECTROLYTE DI, P1

[2] NEUROLEPTIC MALIGNANT SYNDROME WITHOUT NEUROLEPTICS [J].

BRENNAN, D ;

MACMANUS, M ;

HOWE, J ;

MCLOUGHLIN, J .

BRITISH JOURNAL OF PSYCHIATRY, 1988, 152 :578-579

[3]

*BRYST MYERS SQUIB, 1994, SERZ PROD MON

[4]

COHEN BJ, 1990, AM J PSYCHIAT, V147, P948

[5] SEROTONIN SYNDROME FROM TRAZODONE AND BUSPIRONE [J].

GOLDBERG, RJ ;

HUK, M .

PSYCHOSOMATICS, 1992, 33 (02) :235-236

[6]

Ikeda K, 1994, Rinsho Shinkeigaku, V34, P911

[7] EFFECTS OF CHRONIC TREATMENT WITH VALPROATE ON SEROTONIN-1A RECEPTOR-BINDING AND FUNCTION [J].

KHAITAN, L ;

CALABRESE, JR ;

STOCKMEIER, CA .

PSYCHOPHARMACOLOGY, 1994, 113 (3-4) :539-542

[8]

KLINE SS, 1989, CLIN PHARMACY, V8, P510

[9]

MCLEOD S, 1995, CAN J CLIN PHARM, V2, P131

[10] SEROTONIN SYNDROME PRODUCED BY PAROXETINE AND LOW-DOSE TRAZODONE [J].

REEVES, RR ;

BULLEN, JA .

PSYCHOSOMATICS, 1995, 36 (02) :159-160

← 1 2 →