Progress in artificial metallonucleases

被引：159

作者：

Mancin, Fabrizio ^{[1
]}

Scrimin, Paolo ^{[1
]}

Tecilla, Paolo ^{[2
]}

机构：

[1] Univ Padua, Dipartimento Sci Chim, I-35131 Padua, Italy

[2] Univ Trieste, Dipartimento Sci Chim & Farmaceut, I-34127 Trieste, Italy

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 45期

关键词：

DOUBLE-STRAND DNA; DINUCLEAR ZN(II) COMPLEX; PHOSPHATE DIESTER CLEAVAGE; HYDROLYTIC CLEAVAGE; NUCLEASE ACTIVITY; RESTRICTION DNA; ALKALINE-PHOSPHATASE; PHOSPHORYL-TRANSFER; COPPER-COMPLEXES; TRANSITION-STATE;

D O I：

10.1039/c2cc30952a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is still a fascinating challenge. Over the years, many examples have been reported reproducing part of the behaviour of the corresponding natural enzymes. Eventually, even the possibility to apply such systems to the manipulation of DNA of higher organisms has been demonstrated. However, efficiency of enzymes is still unrivalled. This feature article discusses the progress reported toward the realization of synthetic nucleases with particular attention to the comprehension of the reaction mechanisms and to the strategies that need to be addressed to obtain more efficient systems.

引用

页码：5545 / 5559

页数：15

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