Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders

被引：52

作者：

Cataldo, A

Rebeck, GW

Ghetti, B

Hulette, C

Lippa, C

Van Broeckhoven, C

van Duijn, C

Cras, P

Bogdanovic, N

Bird, T

Peterhoff, C

Nixon, R

机构：

[1] Harvard Univ, McLean Hosp, Sch Med, Mailman Res Ctr,Lab Mol Neuropathol, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Res Ctr, Charlestown, MA USA

[3] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

[4] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[5] Med Coll Penn & Hahnemann Univ, Dept Neurol, Philadelphia, PA 19102 USA

[6] Univ Antwerp VIB, Born Bunge Fdn, Dept Mol Genet, B-2020 Antwerp, Belgium

[7] Erasmus Univ, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[8] Univ Antwerp, Born Bunge Fdn, Neurobiol Lab, B-2020 Antwerp, Belgium

[9] Karolinska Inst, Dept Geriatr Med, Inst Clin Neurosci & Family Med, S-10401 Stockholm, Sweden

[10] VA Med Ctr, Dept Geriatr, Seattle, WA USA

[11] Nathan S Kline Inst Psychiat Res, Ctr Dermatia Res, Orangeburg, NY 10962 USA

[12] NYU, Sch Med, Dept Psychiat, New York, NY USA

[13] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

来源：

ANNALS OF NEUROLOGY | 2001年 / 50卷 / 05期

关键词：

D O I：

10.1002/ana.1254

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The endocytic pathway is important in amyloid precursor protein (APP) processing and beta -amyloid formation. Our studies have shown that endocytic pathway activation is a prominent and early feature of neurons in vulnerable regions of the brain in sporadic Alzheimer's disease. We report that endocytic pathway abnormalities are present not only in neurons, but in cerebral endothelia in Alzheimer's disease caused by certain APP mutations. The presence or absence of endocytic abnormalities distinguish subtypes of familial Alzheimer's disease linked to APP mutations from presenilin mutations, supporting the notion that different cellular pathways are involved in the altered processing of APP leading to increased beta -amyloid generation in certain of these different Alzheimer's disease subtypes.

引用

页码：661 / 665

页数：5

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