Determinants of immune reconstitution inflammatory syndrome in HIV type 1 -: Infected patients with tuberculosis after initiation of antiretroviral therapy

被引:197
作者
Breton, G
Duval, X
Estellat, C
Poaletti, X
Bonnet, D
Mvondo, DM
Longuet, P
Leport, C
Vildé, JL
机构
[1] Hop Bichat Claude Bernard, Serv Malad Infect & Trop, Assistance Publ Hop Paris, INSERM,E0357,Dept Infect & Trop Dis, F-75018 Paris, France
[2] Hop Bichat Claude Bernard, Dept Biostat & Epidemiol, Assistance Publ Hop Paris, INSERM,E0357, F-75018 Paris, France
关键词
D O I
10.1086/425742
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immune reconstitution inflammatory syndrome ( IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.
引用
收藏
页码:1709 / 1712
页数:4
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