Polymorphisms in the CD14 gene associated Ewith pulmonary function in farmers

被引:52
作者
LeVan, TD
Von Essen, S [1 ]
Romberger, DJ
Lambert, GP
Martinez, FD
Vasquez, MM
Merchant, JA
机构
[1] Univ Nebraska, Med Ctr, Dept Internal Med, Pulm & Crit Care Med Sect, Omaha, NE 68198 USA
[2] Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Iowa City, IA USA
[3] Univ Arizona, Coll Med, Arizona Resp Ctr, Tucson, AZ USA
[4] Univ Arizona, Coll Med, Dept Internal Med, Tucson, AZ USA
[5] Univ Arizona, Coll Med, Dept Pediat, Tucson, AZ USA
[6] Creighton Univ, Dept Exercise Sci & Athlet Training, Omaha, NE 68178 USA
关键词
endotoxin; farming; lipopolysaccharicle; occupational exposure; wheeze;
D O I
10.1164/rccm.200404-530OC
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Rationale and Objectives: Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin. Materials and Methods: Based on our findings of increased circulating CD14 associated with the CD14/ -159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25-75) (P = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared with farmers with the A allele (n = 86). Results: No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, P = 0-11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) or CD14/-1619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299GIy and lung function or wheeze. Conclusion: We conclude that the CD14/-159 or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers.
引用
收藏
页码:773 / 779
页数:7
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