Investigation of diketopiperazines containing a guanidino-functionalized sidechain as potential catalysts of enantioselective Strecker reactions

被引：31

作者：

Becker, C

Hoben, C

Schollmeyer, D

Scherr, G

Kunz, H

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[2] BASF AG, Global Polymer Res Funct Intermediate Polymers Po, GKF CB1, D-67056 Ludwigshafen, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 08期

关键词：

Enantioselective catalysis; Strecker reaction; alpha-amino acid derivatives; diketopiperazines;

D O I：

10.1002/ejoc.200500044

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diketopiperazine 1 consisting of L-(gamma-guanidino-alpha-amino)butyric acid and L-phenylalanine was synthesized as the hydroacetate and as the hydronitrate. Its structure was confirmed by X-ray analysis. In contrast to reports in the literature (Lipton et al.), compound 1 does not induce enantioselevtive catalysis of Strecker reactions. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).

引用

页码：1497 / 1499

页数：3

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