Nitrone derivatives of trolox as neuroprotective agents

被引：31

作者：

Balogh, GT

Vukics, K

Könczöl, A

Kis-Varga, A

Gere, A

Fischer, J

机构：

[1] Gedeon Richter Chem Works Ltd, H-1475 Budapest, Hungary

[2] Budapest Univ Technol & Econ, H-1111 Budapest, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 12期

关键词：

neuroprotection; free radical scavenging; lipid peroxidation; permanent middle cerebral artery occlusion; nitrone; trolox;

D O I：

10.1016/j.bmcl.2005.04.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe2+-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3012 / 3015

页数：4

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