Synthesis of carbamate-linked lipids for gene delivery

被引：43

作者：

Liu, DL ^{[1
]}

Hu, JJ

Qiao, WH

Li, ZS

Zhang, SB

Cheng, LB

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[2] Dalian Natl Univ, Dept Chem Engn, Dalian 116600, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 12期

关键词：

carbarnate-linked; lipids; gene delivery; structure-function relationship;

D O I：

10.1016/j.bmcl.2005.04.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Series of lipids 1a-d and 2a,b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome-mediated gene delivery. The variable length of carbon chains and quaternary ammonium or neutral tertiary amine heads allowed to find the structure-function relationship of how these factors affect cationic lipids on gene delivery performance. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3147 / 3150

页数：4

共 30 条

[1]

ALQUIST FN, 1939, Patent No. 2147226

[2] DIFFUSION OF UNIVALENT IONS ACROSS LAMELLAE OF SWOLLEN PHOSPHOLIPIDS [J].

BANGHAM, AD ;

STANDISH, MM ;

WATKINS, JC .

JOURNAL OF MOLECULAR BIOLOGY, 1965, 13 (01) :238-+

[3] A FLEXIBLE APPROACH TO SYNTHETIC LIPID AMMONIUM-SALTS FOR POLYNUCLEOTIDE TRANSFECTION [J].

BENNETT, MJ ;

MALONE, RW ;

NANTZ, MH .

TETRAHEDRON LETTERS, 1995, 36 (13) :2207-2210

[4] Formation of plasmid-based transfection complexes with an acid-labile cationic lipid:: characterization of in vitro and in vivo gene transfer [J].

Boomer, JA ;

Thompson, DH ;

Sullivan, SM .

PHARMACEUTICAL RESEARCH, 2002, 19 (09) :1292-1301

[5] Synthesis of acid-labile diplasmenyl lipids for drug and gene delivery applications [J].

Boomer, JA ;

Thompson, DH .

CHEMISTRY AND PHYSICS OF LIPIDS, 1999, 99 (02) :145-153

[6] INHIBITION OF PROTEIN-KINASE-C BY CATIONIC AMPHIPHILES [J].

BOTTEGA, R ;

EPAND, RM .

BIOCHEMISTRY, 1992, 31 (37) :9025-9030

[7] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[8] The future of gene therapy [J].

Cavazzana-Calvo, M ;

Thrasher, A ;

Mavilio, F .

NATURE, 2004, 427 (6977) :779-781

[9]

Cotarca L, 1996, SYNTHESIS-STUTTGART, P553

[10] An overview of current delivery systems in cancer gene therapy [J].

El-Aneed, A .

JOURNAL OF CONTROLLED RELEASE, 2004, 94 (01) :1-14

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