Genetic risk profiles for depression and anxiety in adult and elderly cohorts

被引：112

作者：

Demirkan, A. ^{[1
,2
]}

Penninx, B. W. J. H. ^{[3
]}

Hek, K. ^{[1
,2
]}

Wray, N. R. ^{[4
]}

Amin, N. ^{[1
,2
]}

Aulchenko, Y. S. ^{[1
,2
]}

van Dyck, R. ^{[3
]}

de Geus, E. J. C. ^{[5
]}

Hofman, A. ^{[1
,2
]}

Uitterlinden, A. G. ^{[1
,2
]}

Hottenga, J-J ^{[5
]}

Nolen, W. A. ^{[6
]}

Oostra, B. A. ^{[1
,2
]}

Sullivan, P. F. ^{[7
,8
]}

Willemsen, G. ^{[5
]}

Zitman, F. G. ^{[9
]}

Tiemeier, H. ^{[1
,2
]}

Janssens, A. C. J. W. ^{[1
,2
]}

Boomsma, D. I. ^{[5
]}

van Duijn, C. M. ^{[1
,2
]}

Middeldorp, C. M. ^{[5
,10
]}

机构：

[1] Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands

[2] Erasmus MC, Genet Epidemiol Unit, Dept Clin Genet, Rotterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands

[4] Queensland Inst Med Res, Genet Epidemiol Unit, Brisbane, Qld 4006, Australia

[5] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands

[7] Univ N Carolina, Dept Genet, Chapel Hill, NC USA

[8] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[9] Leiden Univ Med Ctr, Dept Psychiat, Leiden, Netherlands

[10] Acad Ctr Child & Adolescent Psychiat, Amsterdam, Netherlands

来源：

MOLECULAR PSYCHIATRY | 2011年 / 16卷 / 07期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

depression; anxiety; polygenic; genome-wide association; risk score; GENOME-WIDE ASSOCIATION; SCALE CES-D; MAJOR DEPRESSION; HOSPITAL ANXIETY; CRITERION VALIDITY; HERITABILITY; EPIDEMIOLOGY; DISORDERS; TWINS; LIFE;

D O I：

10.1038/mp.2010.65

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the heritability of psychiatric diseases. The contribution of a large number of genes to complex traits can be analyzed with genome-wide profiling. In a discovery sample, a genetic risk profile for depression was defined based on a GWA study of 1738 adult cases and 1802 controls. The genetic risk scores were tested in two population-based samples of elderly participants. The genetic risk profiles were evaluated for depression and anxiety in the Rotterdam Study cohort and the Erasmus Rucphen Family (ERF) study. The genetic risk scores were significantly associated with different measures of depression and explained up to similar to 0.7% of the variance in depression in Rotterdam Study and up to similar to 1% in ERF study. The genetic score for depression was also significantly associated with anxiety explaining up to 2.1% in Rotterdam study. These findings suggest the presence of many genetic loci of small effect that influence both depression and anxiety. Remarkably, the predictive value of these profiles was as large in the sample of elderly participants as in the middle-aged samples. Molecular Psychiatry (2011) 16, 773-783; doi:10.1038/mp.2010.65; published online 22 June 2010

引用

页码：773 / 783

页数：11

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