Th2 cytokines and asthma - Interleukin-9 as a therapeutic target for asthma

被引：76

作者：

Zhou, YH ^{[1
]}

McLane, M ^{[1
]}

Levitt, RC ^{[1
]}

机构：

[1] Magainin Pharmaceut Inc, Plymouth Meeting, PA 19462 USA

来源：

RESPIRATORY RESEARCH | 2001年 / 2卷 / 02期

关键词：

asthma; genetics; interleukin-9; target; transgenic;

D O I：

10.1186/rr42

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the T(H)2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other T(H)2 cytokines such as IL-4, IL-5 and IL-13.

引用

页码：80 / 84

页数：5

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