Paracrine actions of the stomach-derived leptin

被引：12

作者：

Buyse, M ^{[1
]}

Aparicio, T ^{[1
]}

Guilmeau, S ^{[1
]}

Goïot, H ^{[1
]}

Sobhani, I ^{[1
]}

Bado, A ^{[1
]}

机构：

[1] INSERM, U410, UFR Xavier Bichat, IFR02 Claude Bernard, F-75870 Paris 18, France

来源：

M S-MEDECINE SCIENCES | 2004年 / 20卷 / 02期

关键词：

D O I：

10.1051/medsci/2004202183

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Paracrine actions of the stomach-derived leptin Leptin, a 16 kilodalton protein-encoded by the ob gene, is involved in the regulation of food intake, body composition, and energy expenditure through a central feedback mechanism. Initially thought to be adipocyte-specific, the ob gene, as well as the leptin receptor, has been found in a variety of other tissues. Relevant to this review, the leptin gene and its receptor have been identified in the stomach, intestine, liver, and pancreas. Recent data also suggest that gut leptin may act locally within the gastrointestinal tract to influence intestinal functions such as nutrient absorption and may have a physiopathological implication. This review emphasises the concept that leptin may be a new gastrointestinal hormone.

引用

页码：183 / 188

页数：6

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