Circulatory miR-34a as an RNA-based, noninvasive biomarker for brain aging

被引：132

作者：

Li, Xiaoli ^{[2
]}

Khanna, Amit ^{[2
]}

Li, Na ^{[2
]}

Wang, Eugenia ^{[1
,2
]}

机构：

[1] Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Louisville, KY 40292 USA

[2] Univ Louisville, Sch Med, Gheens Ctr Aging, Louisville, KY 40292 USA

来源：

AGING-US | 2011年 / 3卷 / 10期

关键词：

MicroRNAs; aging; biomarker; SIRT1; Bcl2; miR-34a; miR-196a; C; ELEGANS; MICRORNA SIGNATURES; SIRT1; EXPRESSION; LIFE-SPAN; DISEASE; P53; CANCER; BLOOD; ALZHEIMERS; APOPTOSIS;

D O I：

10.18632/aging.100371

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs in blood samples have been identified as an important class of biomarkers, which can reflect physiological changes from cancer to brain dysfunction. In this report we identify concordant increases in levels of expression of miR-34a in brain and two components of mouse blood samples, peripheral blood mononuclear cells (PBMCs) and plasma, from 2 day old neonates through young adulthood and mid-life to old age at 25 months. Levels of this microRNA's prime target, silent information regulator 1 (SIRT1), in brain and the two blood-derived specimens decrease with age inversely to miR-34a, starting as early as 4 months old, when appreciable tissue aging has not yet begun. Our results suggest that: 1. Increased miR-34a and the reciprocal decrease of its target, SIRT1, in blood specimens are the accessible biomarkers for age-dependent changes in brain; and 2. these changes are predictors of impending decline in brain function, as early as in young adult mice.

引用

页码：985 / 1002

页数：18

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