ProNGF: a neurotrophic or an apoptotic molecule?

被引:104
作者
Fahnestock, M [1 ]
Yu, GH [1 ]
Coughlin, MD [1 ]
机构
[1] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8N 3Z5, Canada
来源
NGF AND RELATED MOLECULES IN HEALTH AND DISEASE | 2004年 / 146卷
关键词
neurotrophin; precursor; TrkA; p75(NTR); neurite outgrowth; survival;
D O I
10.1016/S0079-6123(03)46007-X
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Nerve growth factor (NGF) acts on various classes of central and peripheral neurons to promote cell survival, stimulate neurite outgrowth and modulate differentiation. NGF is synthesized as a precursor, proNGF, which undergoes processing to generate mature NGF. It has been assumed, based on studies in the mouse submandibular gland, that NGF in vivo is largely mature NGF, and that mature NGF accounts for the molecule's biological activity. However, recently we have shown that proNGF is abundant in central nervous system tissues whereas mature NGF is undetectable, suggesting that proNGF may have a function distinct from its role as a precursor. A recent report that proNGF has apoptotic activity contrasts with other data demonstrating that proNGF has neurotrophic activity. This chapter will review the structure and processing of NGF and what is known about the biological activity of proNGF. Possible reasons for the discrepancies in recent reports are discussed.
引用
收藏
页码:101 / 110
页数:10
相关论文
共 75 条
[1]   P53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors [J].
Aloyz, RS ;
Bamji, SX ;
Pozniak, CD ;
Toma, JG ;
Atwal, J ;
Kaplan, DR ;
Miller, FD .
JOURNAL OF CELL BIOLOGY, 1998, 143 (06) :1691-1703
[2]   NEUROTROPHIC FACTORS AND THEIR RECEPTORS [J].
BARBACID, M .
CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (02) :148-155
[3]   EVIDENCE FOR PRO-BETA-NERVE GROWTH-FACTOR, A BIOSYNTHETIC PRECURSOR TO BETA-NERVE GROWTH-FACTOR - (ARGINYL-ESTEROPEPTIDASE-PROTEIN PROCESSING SUBMAXILLARY GLAND GAMMA-SUBUNIT EPIDERMAL GROWTH-FACTOR) [J].
BERGER, EA ;
SHOOTER, EM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3647-3651
[4]   Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR [J].
Bibel, M ;
Hoppe, E ;
Barde, YA .
EMBO JOURNAL, 1999, 18 (03) :616-622
[5]   Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase [J].
Brann, AB ;
Tcherpakov, M ;
Williams, IM ;
Futerman, AH ;
Fainzilber, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (12) :9812-9818
[6]   HUMAN FUR GENE ENCODES A YEAST KEX2-LIKE ENDOPROTEASE THAT CLEAVES PRO-BETA-NGF INVIVO [J].
BRESNAHAN, PA ;
LEDUC, R ;
THOMAS, L ;
THORNER, J ;
GIBSON, HL ;
BRAKE, AJ ;
BARR, PJ ;
THOMAS, G .
JOURNAL OF CELL BIOLOGY, 1990, 111 (06) :2851-2859
[7]   NERVE GROWTH-FACTOR (NGF), PRONGF AND NGF RECEPTOR-LIKE IMMUNOREACTIVITY IN BB RAT RETINA [J].
CHAKRABARTI, S ;
SIMA, AAF ;
LEE, J ;
BRACHET, P ;
DICOU, E .
BRAIN RESEARCH, 1990, 523 (01) :11-15
[8]   Characterization of nerve growth factor precursor protein expression in rat round spermatids and the trophic effects of nerve growth factor in the maintenance of Sertoli cell viability [J].
Chen, Y ;
Dicou, E ;
Djakiew, D .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1997, 127 (02) :129-136
[9]  
COHEN S, 1959, J BIOL CHEM, V234, P1129