Deep-Tissue Photoacoustic Tomography of a Genetically Encoded Near-Infrared Fluorescent Probe

被引：163

作者：

Filonov, Grigory S. ^{[2
,3
]}

Krumholz, Arie ^{[1
]}

Xia, Jun ^{[1
]}

Yao, Junjie ^{[1
]}

Wang, Lihong V. ^{[1
]}

Verkhusha, Vladislav V. ^{[2
,3
]}

机构：

[1] Washington Univ, Opt Imaging Lab, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, Bronx, NY 10461 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 06期

基金：

美国国家卫生研究院;

关键词：

absorption; cancer; fluorescent proteins; imaging agents; photoacoustic imaging; IN-VIVO; SMALL ANIMALS; PROTEINS; RED; MICROSCOPY;

D O I：

10.1002/anie.201107026

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：1448 / 1451

页数：4

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