An incredible decade for the primary cilium: a look at a once-forgotten organelle

被引:238
作者
Davenport, JR [1 ]
Yoder, BK [1 ]
机构
[1] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA
关键词
cilia; cystic kidney disease; intraflagellar transport; biliary duct; pancreatic duct; hydrocephaly; polydactyly; Bardet-Biedl; nephronophthisis; polycystic kidney disease; situs inversus; mouse models; hedgehog signaling;
D O I
10.1152/ajprenal.00118.2005
中图分类号
Q4 [生理学];
学科分类号
071003 [生理学];
摘要
Since the discovery that numerous proteins involved in mammalian disease localize to the basal bodies and cilia, these organelles have emerged from relative obscurity to the center of intense research efforts in an expanding number of disease- and developmental-related fields. Our understanding of the association between cilia and human disease has benefited substantially from the use of lower organisms such as Chlamydomonas and Caenorhabditis elegans and the availability of murine models and cell culture. These research endeavors led to the discovery that loss of normal ciliary function in mammals is responsible for cystic and noncystic pathology in the kidney, liver, brain, and pancreas, as well as severe developmental patterning abnormalities. In addition, the localization of proteins involved in rare human disorders such as Bardet-Biedl syndrome has suggested that cilia-related dysfunction may play a role in modern human epidemics such as hypertension, obesity, and diabetes. Although we have made great advances in demonstrating the importance of cilia over the past decade, the physiological role that this organelle plays in most tissues remains elusive. Research focused on addressing this issue will be of critical importance for a further understanding of how ciliary dysfunction can lead to such severe disease and developmental pathologies.
引用
收藏
页码:F1159 / F1169
页数:11
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