Synthesis of 10,11-dihydro-12-oxo-LTB(4), a key biochemical intermediate

被引：15

作者：

Khanapure, SP

Wang, SS

Powell, WS

Rokach, J

机构：

[1] FLORIDA INST TECHNOL,CLAUDE PEPPER INST,MELBOURNE,FL 32901

[2] FLORIDA INST TECHNOL,DEPT CHEM,MELBOURNE,FL 32901

[3] MCGILL UNIV,MEAKINS CHRISTIE LABS,MONTREAL,PQ H2X 2P2,CANADA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 02期

关键词：

D O I：

10.1021/jo9614957

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of the 5(S)-hydroxy-10,11-dihydro-12-oxo-6(Z),8(E),14(Z)-eicosatrienoic acid (10,11-dihydro-12-oxo-LTB(4)) (3) is reported. This compound is a key pivotal intermediate in the biotransformation of LTB(4) by the so-called ''LTB(4) reductase pathway''.

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页码：325 / 330

页数：6

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