Sequential transplantation induces islet allograft tolerance

被引：4

作者：

Sun, JH ^{[1
]}

Wang, XY ^{[1
]}

Wang, CM ^{[1
]}

Sheil, AGR ^{[1
]}

机构：

[1] Univ Sydney, Dept Surg, Sydney, NSW 2006, Australia

来源：

MICROSURGERY | 2001年 / 21卷 / 04期

关键词：

D O I：

10.1002/micr.1028

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Liver transplantation (LT) in some rat strain combinations can induce tolerance to other organ grafts of liver donor strain. The aim of the study was to examine the effect of LT on islet allografts. Islets were isolated by collagenase digestion and purified by dextran-gradient separation. Islets from two donor animals (>2,000) were transplanted under the left kidney capsule of streptozotocin-induced diabetic rats. The liver was implanted orthotopically. The results showed that concurrent LT and islet transplantation (IT) prolonged survival of islet allografts modestly, but islet allografts survived indefinitelywhen LT was performed before or after IT. LT delayed or reversed ongoing islet graft rejection. IT could trigger rejection in otherwise tolerated liver grafts. We conclude that sequential IT-LT or LT-IT can induce islet allograft tolerance or liver rejection and that the mechanisms involved may differ from those involved with LT simultaneously with either IT or vascularized organ grafts. (C) 2001 Wiley-Liss, Inc.

引用

页码：148 / 152

页数：5

共 17 条

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