Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

被引：833

作者：

Donnelly, Dustin J. ^{[1
,2
]}

Popovich, Phillip G. ^{[1
,2
]}

机构：

[1] Ohio State Univ, CBSCR, Dept mol Virol Immunol & Med Genet, Integrat Biomed Sci Grad Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Inst Behav Med Res, Columbus, OH 43210 USA

来源：

EXPERIMENTAL NEUROLOGY | 2008年 / 209卷 / 02期

基金：

美国国家卫生研究院;

关键词：

macrophages; lymphocytes; neuroinflammation; spinal cord injury; traumatic brain injury; blood-brain barrier;

D O I：

10.1016/j.expneurol.2007.06.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based therapies are becoming a therapeutic focus. This review will address the complexities and controversies of post-traumatic neuroinflammation, particularly in spinal cord. In addition, current therapies designed to target neuroinflammatory cascades will be discussed. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：378 / 388

页数：11

共 190 条

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Spinal cord injury triggers systemic autoimmunity: evidence for chronic B lymphocyte activation and lupus-like autoantibody synthesis [J].