Hypoxia inducible factor (HIF) in rheumatology:: low O2!: See what HIF can do!

被引：137

作者：

Gaber, T

Dziurla, R

Tripmacher, R

Burmester, GR

Buttgereit, F

机构：

[1] Humboldt Univ, Charite Univ Hosp, Dept Rheumatol & Clin Immunol, D-10117 Berlin, Germany

[2] Deutsdch Rheumaforschungszentrum Berlin, D-10117 Berlin, Germany

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2005年 / 64卷 / 07期

关键词：

D O I：

10.1136/ard.2004.031641

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maintenance of oxygen homoeostasis is the basic principle in cell proliferation, differentiation, survival, and function in all higher organisms. The transcription factor, HIF ( hypoxia inducible factor) has a central role in oxygen homoeostasis, and is indispensably linked to energy metabolism. Abnormally reduced oxygen concentrations leading to dysfunctional cell metabolism are found in rheumatoid arthritis and hence, knowledge of the molecular adaptive responses to hypoxia and the involvement of HIF in the pathogenesis of RA are interesting.

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收藏

页码：971 / 980

页数：10

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