Containment sensors for the determination of L-lactate and glucose

被引：45

作者：

Perdomo, J

Sundermeier, C

Hinkers, H

Morell, OM

Seifert, W

Knoll, M

机构：

[1] Inst Chemo & Biosensorik, ICB, D-48149 Muenster, Germany

[2] Fachhsch Muenster, D-48565 Steinfurt, Germany

[3] Inst Super Politecn Jose A Echeverria, Ctr Invest Microelect, Havana 8, Cuba

来源：

BIOSENSORS & BIOELECTRONICS | 1999年 / 14卷 / 01期

关键词：

enzyme sensor; containment sensor; lactate sensor; glucose sensor; miniaturization; mass-production technology;

D O I：

10.1016/S0956-5663(98)00104-3

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This paper reports some new results on enzyme based silicon containment sensors. For the first time an L-lactate sensor in containment technology is presented. Through optimization of the buffer system the stability of the lactate sensor was enhanced and the linear response of over 10 mM was achieved. The glucose sensor has also been optimized for a large linear measurement range exceeding 30 mM. A two-enzyme chip with glucose and lactate sensor elements which were integrated on one silicon chip is presented. The response behaviour of the two-enzyme chip was very similar to the single chip behaviour, No cross-talking effects could be observed. A fabrication process for mass-production is described. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：27 / 32

页数：6

共 21 条

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Conrath N, 1997, TRANSDUCERS 97 - 1997 INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS AND ACTUATORS, DIGEST OF TECHNICAL PAPERS, VOLS 1 AND 2, P481, DOI 10.1109/SENSOR.1997.613691

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