Lipobeads: A hydrogel anchored lipid vesicle system

被引：62

作者：

Jin, T

Pennefather, P

Lee, PI

机构：

[1] UNIV TORONTO,FAC PHARM,TORONTO,ON M5S 2S2,CANADA

[2] SCHERING PLOUGH CORP,RES INST,KENILWORTH,NJ 07033

来源：

FEBS LETTERS | 1996年 / 397卷 / 01期

关键词：

supported lipid bilayer; hydrogel microsphere; polyvinyl alcohol; liposome; model membrane; artificial cell;

D O I：

10.1016/S0014-5793(96)01021-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new vesicle system is described that combines complementary properties of liposomes and polymeric beads. 'Lipobeads' consist of a lipid bilayer shell anchored on the surface of a hydrogel polymer cores which acts like a cytoskeleton. Anchoring is provided by fatty acids covalently attached to the surface of the hydrogel. These hydrophobic chains drive spontaneous assembly of a lipid bilayer shell around the modified hydrogel bead when exposed to a suspension of liposomes, The bilayer is stable and acts as a permeability barrier to compound loaded by prior absorption into the polymer core. Lipid mobility in the shell is similar to that found in other unanchored lipid bilayers. The system has potential application in drug delivery and for functional reconstitution of membrane proteins.

引用

页码：70 / 74

页数：5

共 25 条

[1] LATERAL DIFFUSION AND PERCOLATION IN 2-PHASE, 2-COMPONENT LIPID BILAYERS - TOPOLOGY OF THE SOLID-PHASE DOMAINS INPLANE AND ACROSS THE LIPID BILAYER [J].