Relationships Between Biochemical Markers of Hyperandrogenism and Metabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

被引:21
作者
Amiri, Mina [1 ]
Tehrani, Fahimeh Ramezani [1 ]
Bidhendi-Yarandi, Razieh [1 ,2 ]
Behboudi-Gandevani, Samira [1 ]
Azizi, Fereidoun [3 ]
Carmina, Enrico [4 ]
机构
[1] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Tehran, Iran
[4] Univ Palermo, Dept Hlth Sci & Mother & Child Care, Endocrinol Unit, Palermo, Italy
关键词
meta-analysis; polycystic ovary syndrome; Ferriman-Gallwey score; metabolic disorder; insulin resistance; ESTRADIOL-CYPROTERONE ACETATE; ETHINYL ESTRADIOL; ORAL-CONTRACEPTIVES; ANDROGEN EXCESS; SYNDROME PCOS; LUTEINIZING-HORMONE; YOUNG-WOMEN; DROSPIRENONE; METFORMIN; INSULIN;
D O I
10.1055/a-0806-8281
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
While several studies have documented an increased risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS), associations between androgenic and metabolic parameters in these patients are unclear. We aimed to investigate the relationships between biochemical markers of hyperandrogenism (HA) and metabolic parameters in women with PCOS. In this systematic review and meta-analysis, a literature search was performed in the PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science from 2000 to 2018 for assessing androgenic and metabolic parameters in PCOS patients. To assess the relationships between androgenic and metabolic parameters, meta-regression analysis was used. A total number of 33 studies involving 9905 patients with PCOS were included in this analysis. The associations of total testosterone (tT) with metabolic parameters were not significant; after adjustment for age and BMI, we detected associations of this androgen with low-density lipoproteins cholesterol (LDL-C) (=0.006; 95% CI: 0.002, 0.01), high-density lipoproteins cholesterol (HDL-C) (=-0.009; 95% CI: -0.02, -0.001), and systolic blood pressure (SBP) (=-0.01; 95% CI: -0.03, -0.00). We observed a positive significant association between free testosterone (fT) and fasting insulin (=0.49; 95% CI: 0.05, 0.91); this association remained significant after adjustment for confounders. We also detected a reverse association between fT and HDL-C (=-0.41; 95% CI: -0.70, -0.12). There was a positive significant association between A4 and TG (=0.02; 95% CI: 0.00, 0.04) after adjustment for PCOS diagnosis criteria. We also found significant negative associations between A4, TC, and LDL-C. Dehydroepiandrosterone sulfate (DHEAS) had a positive association with LDL-C (=0.02; 95% CI: 0.001, 0.03) and a reverse significant association with HDL-C (=-0.03; 95% CI: -0.06, -0.001). This meta-analysis confirmed the associations of some androgenic and metabolic parameters, indicating that measurement of these parameters may be useful for predicting metabolic risk in PCOS patients.
引用
收藏
页码:22 / 34
页数:13
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