Cholinergic agonists attenuate renal ischemia-reperfusion injury in rats

被引：121

作者：

Yeboah, M. M. ^{[1
,2
]}

Xue, X. ^{[1
]}

Duan, B. ^{[3
]}

Ochani, M. ^{[4
]}

Tracey, K. J. ^{[4
]}

Susin, M. ^{[5
]}

Metz, C. N. ^{[1
]}

机构：

[1] N Shore LIJ Hlth Syst, Feinstein Inst Med Res, Susan & Herman Merinoff Ctr Patient Oriented Res, Med Biochem Lab, Manhasset, NY 11030 USA

[2] N Shore LIJ Grad Sch Mol Med, Manhasset, NY USA

[3] Ang Biomed Corp, Garden City, NY USA

[4] N Shore LIJ Hlth Syst, Feinstein Inst Med Res, Lab Biomed Sci, Garden City, NY USA

[5] N Shore Univ Hosp, Dept Pathol, Manhasset, NY USA

来源：

KIDNEY INTERNATIONAL | 2008年 / 74卷 / 01期

关键词：

inflammation; renal ischemia-reperfusion injury; TNF; nicotine; GTS-21; tubular epithelial cells;

D O I：

10.1038/ki.2008.94

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammation plays a significant role in the pathophysiology of renal ischemia-reperfusion injury. Local inflammation is modulated by the brain via the vagus nerve and nicotinic acetylcholine receptors such that electrical or pharmacologic stimulation of this cholinergic anti-inflammatory pathway results in suppression of proinflammatory cytokine production. We examined the effects of cholinergic stimulation using agonists, nicotine or GTS-21, given before or after bilateral renal ischemia-reperfusion injury in rats. Pretreatment of rats with either agonist significantly attenuated renal dysfunction and tubular necrosis induced by renal ischemia. Similarly, tumor necrosis factor-alpha protein expression and leukocyte infiltration of the kidney were markedly reduced following treatment with cholinergic agonists. We found functional nicotinic acetylcholine receptors were present on rat proximal tubule epithelial cells. Cholinergic stimulation significantly decreased tubular necrosis in vagotomized rats after injury, implying an intact vagus nerve is not required for this renoprotective effect.

引用

页码：62 / 69

页数：8

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