Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes

被引:54
作者
Hong, Su Jin [1 ,2 ]
Kim, Tae Jung [1 ,3 ]
Choi, Yo Won [2 ]
Park, Jeong-Soo [4 ]
Chung, Jin-Haeng [5 ]
Lee, Kyung Won [1 ]
机构
[1] Seoul Natl Univ, Bundang Hosp, Dept Radiol, 300 Gumi Dong, Songnam 463707, Gyeonggi Do, South Korea
[2] Hanyang Univ, Sch Med, Dept Radiol, Seoul, South Korea
[3] Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea
[4] Dankook Univ, Dept Biochem, Coll Med, Cheonan, South Korea
[5] Seoul Natl Univ, Bundang Hosp, Dept Pathol, 300 Gumi Dong, Songnam 463707, Gyeonggi Do, South Korea
关键词
Computed tomography (CT); Lung; Adenocarcinoma; Epidermal growth factor receptor (EGFR); Mutation; GROUND-GLASS OPACITY; BRONCHIOLOALVEOLAR PATHOLOGICAL SUBTYPE; RESOLUTION COMPUTED-TOMOGRAPHY; LYMPH-NODE METASTASIS; PULMONARY ADENOCARCINOMA; GENE MUTATION; CANCER; EGFR; CLASSIFICATION; ASSOCIATION;
D O I
10.1007/s00330-015-4196-z
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To correlate imaging features of resected lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation and the IASLC/ATS/ERS classification histological subtypes. In 250 consecutive patients with resected lung adenocarcinoma, EGFR mutation status was correlated with demographics, imaging features including ground-glass opacity (GGO) proportion and the IASLC/ATS/ERS classification histological subtypes. EGFR mutations were significantly more frequent in women (54.5 % vs. 38.1 %, p = 0.011) and in never-smokers (54.7 % vs. 35.3 %, p = 0.003). GGO proportion was significantly higher in tumours with EGFR mutation than in those without (30.3 +/- 33.8 % vs. 19.0 +/- 29.3 %, p = 0.005). EGFR mutation was significantly more frequent in tumours with GGO aeyen 50 % and tumours with any GGO (p = 0.026 and 0.008, respectively). Adenocarcinomas with exon 19 or 21 mutation showed significantly higher GGO proportion than that in EGFR wild-type tumours (p = 0.009 and 0.029, respectively). Absence of GGO was an independent predictor of negative EGFR mutation (odds ratio, 1.81; 95 % confidence interval, 1.16-3.04; p = 0.018). GGO proportion in adenocarcinomas with EGFR mutation was significantly higher than that in EGFR wild-type tumours, and the absence of GGO on CT was an independent predictor of negative EGFR mutation. aEuro cent Ground-glass opacity (GGO) proportion is significantly higher in EGFR-mutated adenocarcinomas aEuro cent Exon 19 or 21 mutated adenocarcinomas shows significantly higher GGO proportion aEuro cent GGO absence is an independent predictor of negative EGFR mutation in lung adenocarcinomas.
引用
收藏
页码:3660 / 3668
页数:9
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