Evidence that porcine native 5-HT3 receptors do not contain nicotinic acetylcholine receptor subunits

被引：18

作者：

Fletcher, S ^{[1
]}

Lindstrom, JM

McKernan, RM

Barnes, NM

机构：

[1] Univ Birmingham, Sch Med, Dept Pharmacol, Birmingham B15 2TT, W Midlands, England

[2] Univ Penn, Med Ctr, Philadelphia, PA 19104 USA

[3] Merck Sharp & Dohme Res Labs, Ctr Res Neurosci, Harlow CM20 2QR, Essex, England

来源：

NEUROPHARMACOLOGY | 1998年 / 37卷 / 03期

基金：

英国惠康基金;

关键词：

5-HT3; receptor; 5-HT3-A; nicotinic acetylcholine receptor subunits; ligand gated ion channel;

D O I：

10.1016/S0028-3908(98)00052-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present investigation utilised monoclonal antibodies directed against subunits of the nicotinic acetylcholine receptor in immunoblot and immunoprecipitation studies, which failed to demonstrate that the native 5-hydroxytryptamine(3) (5-HT3) receptor complex purified from porcine brain contains the alpha(1), alpha(3), alpha(4), alpha(5), alpha(7), or beta(2) subunits of the nicotinic acetylcholine receptor. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：397 / 399

页数：3

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