Epstein-Barr virus and Hodgkin's disease: Further evidence for the three disease hypothesis

被引：115

作者：

Armstrong, AA

Alexander, FE

Cartwright, R

Angus, B

Krajewski, AS

Wright, DH

Lee, F

Kane, E

Jarrett, RF

机构：

[1] Univ Glasgow, LFR Virus Ctr, Dept Vet Pathol, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Edinburgh, Sch Med, Dept Publ Hlth Sci, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, Sch Med, Dept Pathol, Edinburgh, Midlothian, Scotland

[4] Univ Leeds, LRF Ctr Clin Epidemiol, Leeds, W Yorkshire, England

[5] Royal Victoria Infirm, Sch Pathol Sci, Div Pathol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[6] Univ Southampton, Sch Med, Dept Pathol, Southampton, Hants, England

[7] Univ Glasgow, Western Infirm, Dept Pathol, Glasgow G11 6NT, Lanark, Scotland

[8] Univ Glasgow, Royal Infirm, Dept Pathol, Glasgow G31 2ER, Lanark, Scotland

来源：

LEUKEMIA | 1998年 / 12卷 / 08期

关键词：

Hodgkin's disease; Epstein-Barr virus; epidemiology;

D O I：

10.1038/sj.leu.2401097

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidemiology of Hodgkin's disease suggests that it is a heterogeneous condition comprising more than one disease entity. The Epstein-Barr Virus (EBV) is present in the Reed-Sternberg cells of a proportion of cases and is likely to play a role in the pathogenesis of these cases. In this study we show that EBV association rates vary with age at diagnosis. We suggest that Hodgkin's disease can be divided into three disease entities on the basis of EBV association and age, thereby providing biological support for the multiple aetiology hypothesis proposed by MacMahon (Cancer Res 1966; 26: 1189-1290).

引用

页码：1272 / 1276

页数：5

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