Water-soluble propofol analogues with intravenous anaesthetic activity

被引：14

作者：

Cooke, A ^{[1
]}

Anderson, A

Buchanan, K

Byford, A

Gemmell, D

Hamilton, N

McPhail, P

Miller, S

Sundaram, H

Vijn, P

机构：

[1] Organon Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland

[2] Organon Labs Ltd, Dept Pharmacol, Newhouse ML1 5SH, Scotland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)00088-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：927 / 930

页数：4

共 9 条

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