Prevention of allogeneic fetal rejection by tryptophan catabolism

被引：2044

作者：

Munn, DH

Zhou, M

Attwood, JT

Bondarev, I

Conway, SJ

Marshall, B

Brown, C

Mellor, AL

机构：

[1] Med Coll Georgia, Inst Mol Med & Genet, Program Mol Immunol, Augusta, GA 30912 USA

[2] Med Coll Georgia, Inst Mol Med & Genet, Program Dev Biol, Augusta, GA 30912 USA

[3] Med Coll Georgia, Dept Pediat, Augusta, GA 30912 USA

[4] Univ Georgia, Dept Pathol, Athens, GA 30602 USA

来源：

SCIENCE | 1998年 / 281卷 / 5380期

关键词：

D O I：

10.1126/science.281.5380.1191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the Laws of tissue transplantation. Rapid T cell-induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection.

引用

页码：1191 / 1193

页数：3

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