[Phe1ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2 acts as an agonist of the orphanin FQ nociceptin receptor in vivo

被引：37

作者：

Grisel, JE ^{[1
]}

Farrier, DE

Wilson, SG

Mogil, JS

机构：

[1] Furman Univ, Dept Psychol, Greenville, SC 29613 USA

[2] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA

[3] Univ Illinois, Program Neurosci, Champaign, IL 61820 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 357卷 / 01期

关键词：

anti-opioid; ORL1; receptor; morphine;

D O I：

10.1016/S0014-2999(98)00567-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The orphanin FQ/nociceptin (OFQ/N) derivative peptide, [Phe(1)Psi(CH2-NH)Gly(2)] nociceptin-(1-13)-NH2 (Phe Psi), has been claimed to be both an antagonist and an agonist of the orphan opioid receptor (ORL1) in different in vitro assays. We now report the dose-dependent inhibition of morphine analgesia by Phe Psi in mice, an effect parallel to that of OFQ/N. Further, the anti-opioid actions of OFQ/N are not blocked by Phe Psi. Thus, Phe Psi acts as an ORL1 receptor agonist, not an antagonist, in vivo. (C) 1998 Elsevier Science B.V. All rights reserved.

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页码：R1 / R3

页数：3

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