Large clostridial cytotoxins - A family of glycosyltransferases modifying small GTP-binding proteins

被引：195

作者：

vonEichelStreiber, C

Boquet, P

Sauerborn, M

Thelestam, M

机构：

[1] FAC MED NICE, INSERM, U452, F-06107 NICE 2, FRANCE

[2] CCLRC DARESBURY LAB, SYNCHROTRON RADIAT DEPT, WARRINGTON WA4 4AD, CHESHIRE, ENGLAND

[3] KAROLINSKA INST, CTR MICROBIOL & TUMORBIOL, S-17177 STOCKHOLM, SWEDEN

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 10期

关键词：

D O I：

10.1016/0966-842X(96)10061-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Some Clostridium species produce AB(x)-type protein cytotoxins of high molecular weight. These toxins constitute the group of large clostridial cytotoxins (LCTs), which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily. These characteristics render the LCTs valuable tools for developmental and cell biologists.

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页码：375 / 382

页数：8

相关论文

共 55 条

[1]

MUTAGENESIS OF THE CLOSTRIDIUM-DIFFICILE TOXIN-B GENE AND EFFECT ON CYTOTOXIC ACTIVITY [J].

BARROSO, LA ;

MONCRIEF, JS ;

LYERLY, DM ;

WILKINS, TD .

MICROBIAL PATHOGENESIS, 1994, 16 (04) :297-303

[2]

A COMPARATIVE BIOCHEMICAL, PHARMACOLOGICAL AND IMMUNOLOGICAL STUDY OF CLOSTRIDIUM-NOVYI ALPHA-TOXIN, CLOSTRIDIUM-DIFFICILE TOXIN-B AND C-SORDELLII LETHAL TOXIN [J].

BETTE, P ;

OKSCHE, A ;

MAULER, F ;

VONEICHELSTREIBER, C ;

POPOFF, MR ;

HABERMANN, E .

TOXICON, 1991, 29 (07) :877-887

[3]

PROTEINS REGULATING RAS AND ITS RELATIVES [J].

BOGUSKI, MS ;

MCCORMICK, F .

NATURE, 1993, 366 (6456) :643-654

[4]

BOQUET P, 1995, METHOD ENZYMOL, V256, P297

[5]

BOURNE HR, 1991, NATURE, V349, P117, DOI 10.1038/349117a0

[6]

GTPASE CASCADES CHOREOGRAPHING CELLULAR BEHAVIOR - MOVEMENT, MORPHOGENESIS, AND MORE [J].

CHANT, J ;

STOWERS, L .

CELL, 1995, 81 (01) :1-4

[7]

UDP-glucose deficiency in a mutant cell line protects against glucosyltransferase toxins from Clostridium difficile and Clostridium sordellii [J].

ChavesOlarte, E ;

Florin, I ;

Boquet, P ;

Popoff, M ;

vonEichelStreiber, C ;

Thelestam, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (12) :6925-6932

[8]

COTRANSLATIONAL FOLDING AND CALNEXIN BINDING DURING GLYCOPROTEIN-SYNTHESIS [J].

CHEN, W ;

HELENIUS, J ;

BRAAKMAN, I ;

HELENIUS, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6229-6233

[9]

THE CRYSTAL-STRUCTURE OF DIPHTHERIA-TOXIN [J].

CHOE, S ;

BENNETT, MJ ;

FUJII, G ;

CURMI, PMG ;

KANTARDJIEFF, KA ;

COLLIER, RJ ;

EISENBERG, D .

NATURE, 1992, 357 (6375) :216-222

[10]

THE SMALL GTP-BINDING PROTEIN-RHO REGULATES A PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE IN MAMMALIAN-CELLS [J].

CHONG, LD ;

TRAYNORKAPLAN, A ;

BOKOCH, GM ;

SCHWARTZ, MA .

CELL, 1994, 79 (03) :507-513

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