Gradual adaptation of HIV to human host populations: good or bad news?

被引：54

作者：

Brander, C ^{[1
]}

Walker, BD

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Div AIDS, Boston, MA 02114 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 11期

关键词：

D O I：

10.1038/nm941

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The continuous evolution and adaptation of HIV to its host has produced extensive global viral diversity. Understanding the kinetics and directions of this continuing adaptation and its impact on viral fitness, immunogenicity and pathogenicity will be crucial to the successful design of effective HIV vaccines. Here we discuss some potential scenarios of viral and host coevolution.

引用

页码：1359 / 1362

页数：4

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