Ibuprofenamide: a convenient method of synthesis by catalytic hydration of 2-(4-isobutylphenyl)propionitrile in pure aqueous medium

被引：29

作者：

Garcia-Alvarez, Rocio ^{[1
]}

Francos, Javier ^{[1
]}

Crochet, Pascale ^{[1
]}

Cadierno, Victorio ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Inst Univ Quim Organomet Enrique Moles, Dept Quim Organ & Inorgan,Unidad Asociada,CSIC, E-33006 Oviedo, Spain

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 32期

关键词：

Non-steroidal anti-inflammatory drugs; Ibuprofenamide; Nitrile hydration; Microwave irradiation; Ruthenium; STEREOSELECTIVE HYDROLYSIS; AMIDES; PRODRUGS; NITRILE; LIGANDS; PROSTAGLANDIN; INHIBITORS; COMPLEXES; CHEMISTRY; BEHAVIOR;

D O I：

10.1016/j.tetlet.2011.06.026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical synthesis of the non-steroidal anti-inflammatory drug (NSAID) ibuprofenamide by catalytic hydration of 2-(4-isobutylphenyl)propionitrile is described. The readily accessible areneruthenium(II) complex [RuCl2(eta(6)-C6Me6){P(NMe2)(3)}] is used as the catalyst, pure water as the solvent, and microwave irradiation as the heating source. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4218 / 4220

页数：3

共 57 条

[1] Frontiers in catalytic nitrile hydration: Nitrile and cyanohydrin hydration catalyzed by homogeneous organometallic complexes [J].