Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

被引:5116
作者
Fauser, BCJM [1 ]
Chang, J [1 ]
Azziz, R [1 ]
Legro, R [1 ]
Dewailly, D [1 ]
Franks, S [1 ]
Tarlatzis, BC [1 ]
Fauser, B [1 ]
Balen, A [1 ]
Bouchard, P [1 ]
Dahlgren, E [1 ]
Devoto, L [1 ]
Diamanti, E [1 ]
Dunaif, A [1 ]
Filicori, M [1 ]
Homburg, R [1 ]
Ibanez, L [1 ]
Laven, J [1 ]
Magoffin, D [1 ]
Nestler, J [1 ]
Norman, RJ [1 ]
Pasquali, R [1 ]
Pugeat, M [1 ]
Strauss, J [1 ]
Tan, S [1 ]
Taylor, A [1 ]
Wild, R [1 ]
Wild, S [1 ]
Ehrmann, D [1 ]
Lobo, R [1 ]
机构
[1] Erasmus MC, Ctr Reprod Med, NL-3015 GD Rotterdam, Netherlands
关键词
diagnostic criteria; long-term health risks; polycystic ovary syndrome; revised; 2003; consensus;
D O I
10.1093/humrep/deh098
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
Since the 1990 NIH-sponsored conference on polycystic ovary syndrome (PCOS), it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria. The 2003 Rotterdam consensus workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features hyperandrogenism and polycystic ovary (PCO) morphology. PCOS remains a syndrome and, as such, no single diagnostic criterion (such as hyperandrogenism or PCO) is sufficient for clinical diagnosis. Its clinical manifestations may include: menstrual irregularities, signs of androgen excess, and obesity. Insulin resistance and elevated serum LH levels are also common features in PCOS. PCOS is associated with an increased risk of type 2 diabetes and cardiovascular events.
引用
收藏
页码:41 / 47
页数:7
相关论文
共 94 条
[1]
PREVALENCE OF POLYCYSTIC OVARIES IN WOMEN WITH ANOVULATION AND IDIOPATHIC HIRSUTISM [J].
ADAMS, J ;
POLSON, DW ;
FRANKS, S .
BRITISH MEDICAL JOURNAL, 1986, 293 (6543) :355-359
[2]
Meta-analysis of recombinant versus urinary-derived FSH: an update [J].
Al-Inany, H ;
Aboulghar, M ;
Mansour, R ;
Serour, G .
HUMAN REPRODUCTION, 2003, 18 (02) :305-313
[3]
[Anonymous], 1995, Hum Reprod, V10, P1549
[4]
A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain [J].
Asunción, M ;
Calvo, RM ;
San Millán, JL ;
Sancho, J ;
Avila, S ;
Escobar-Morreale, HF .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (07) :2434-2438
[5]
Screening for 21-hydroxylase-deficient nonclassic adrenal hyperplasia among hyperandrogenic women: a prospective study [J].
Azziz, R ;
Hincapie, LA ;
Knochenhauer, ES ;
Dewailly, D ;
Fox, L ;
Boots, LR .
FERTILITY AND STERILITY, 1999, 72 (05) :915-925
[6]
Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: A multicenter, double blind, placebo-controlled trial [J].
Azziz, R ;
Ehrmann, D ;
Legro, RS ;
Whitcomb, RW ;
Hanley, R ;
Fereshetian, AG ;
O'Keefe, M ;
Ghazzi, MN .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (04) :1626-1632
[7]
MISCARRIAGE RATES FOLLOWING INVITRO FERTILIZATION ARE INCREASED IN WOMEN WITH POLYCYSTIC OVARIES AND REDUCED BY PITUITARY DESENSITIZATION WITH BUSERELIN [J].
BALEN, AH ;
TAN, SL ;
MACDOUGALL, J ;
JACOBS, HS .
HUMAN REPRODUCTION, 1993, 8 (06) :959-964
[8]
POLYCYSTIC-OVARY-SYNDROME - THE SPECTRUM OF THE DISORDER IN 1741 PATIENTS [J].
BALEN, AH ;
CONWAY, GS ;
KALTSAS, G ;
TECHATRAISAK, K ;
MANNING, PJ ;
WEST, C ;
JACOBS, HS .
HUMAN REPRODUCTION, 1995, 10 (08) :2107-2111
[9]
BALEN AH, 2003, IN PRESS HUM REPROD
[10]
Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years [J].
Bili, H ;
Laven, J ;
Imani, B ;
Eijkemans, MJC ;
Fauser, BCJM .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2001, 145 (06) :749-755