Simian immunodeficiency virus macaque models of HIV latency

被引：25

作者：

Deere, Jesse D. ^{[1
]}

Schinazi, Raymond F. ^{[3
]}

North, Thomas W. ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Vet Mol Biosci, Davis, CA 95616 USA

[3] Emory Univ, Sch Med, Vet Affairs Med Ctr, Decatur, GA 30033 USA

来源：

CURRENT OPINION IN HIV AND AIDS | 2011年 / 6卷 / 01期

关键词：

latency; nonhuman primate model of AIDS therapy; RT-SHIV; simian immunodeficiency virus; viral persistence; ACTIVE ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE INHIBITORS; CD4(+) T-CELLS; RHESUS MACAQUES; VIRAL RESERVOIRS; ANIMAL-MODEL; INFECTION; TYPE-1; VIREMIA; RESISTANCE;

D O I：

10.1097/COH.0b013e32834086ce

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Purpose of review This review will focus on recent developments in several nonhuman primate models of AIDS. These models are being used to address viral latency and persistence during antiretroviral therapy in studies that are not feasible in humans. Recent findings Further characterization of the various macaque models of AIDS has demonstrated that several aspects of viral persistence during antiretroviral therapy model HIV-1 infection in humans, including viral decay kinetics. Widespread distribution of viral RNA and viral DNA has been detected in many tissue organs. In addition, the brain has been identified as a site of persistent viral DNA. Summary The macaque models of AIDS are well suited for addressing viral persistence during antiretroviral therapy, including viral latency, residual replication, and tissue organ distribution.

引用

页码：57 / 61

页数：5

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