Expression of nerve growth factors in pancreatic neural tissue and pancreatic cancer

被引:59
作者
Schneider, MB
Standop, J
Ulrich, A
Wittel, U
Friess, H
Andrén-Sandberg, Å
Pour, PM
机构
[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA
[2] Univ Bern, Inselspital, Viszeral & Transplantat Chirurg Klin, CH-3010 Bern, Switzerland
[3] Lund Univ, Dept Surg, Lund, Sweden
关键词
nerve growth factor; pancreas; carcinoma; invasion; nerves; immunohistochemistry;
D O I
10.1177/002215540104901002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
One of the characteristics of pancreatic cancer is its tendency to invade neural tissue. We hypothesized that the affinity of cancer cells for nerve tissue is related to the presence of growth factors in neural tissue and their receptors in cancer cells. Sections of pancreatic cancer and normal pancreatic tissue were examined by immunohistochemistry for the expression of the neurotrophins NGF, BDNF, NT-3, NT-4, and their receptors TrkA, TrkB, and TrkC, as well as the low-affinity receptor, p75(NTR). TrkA expression was found in duct, islet, and cancer cells; TrkB was found in the a-cells of the islet only. The anti-pan-Trk antibody (TrkB3), which is presumed to recognize all three receptors, immunoreacted with duct and acinar cells in normal tissue and with cancer cells. The staining with TrkC was similar to that of TrkA. The low-affinity receptor p75NTR was expressed in the neural tissue and in scattered duct cells of the normal tissue only. Duct and acinar cells, as well as neural tissue and cancer cells, showed weak to strong immunoreactivity with NGF. NT-3 expression was noted in capillary enclothelia and erythrocytes. NT-4 showed specific staining for ductule cells. The expression and distribution of neurotrophins and their receptors suggest their role in the potential of pancreatic cancer cells for neural invasion.
引用
收藏
页码:1205 / 1210
页数:6
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