Autoimmune liver diseases - Recurrence after liver transplantation

Primary biliary cirrhosis and autoimmune hepatitis recur after orthotopic liver transplantation. The recurrence of primary sclerosing cholangitis is less clear. Recurrence of these diseases seems to be of relatively little importance in the short term; however, long-term follow-up is required to address the significance of recurrent disease. Immunosuppression in these patients may alter the natural history of these entities in the post-transplant setting.