Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones

被引：72

作者：

Foroumadi, A

Emami, S

Mehni, M

Moshafi, MH

Shafiee, A ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Chem & Pharmaceut Sci, Res Ctr, Tehran 14174, Iran

[2] Mazandaran Univ Med Sci, Fac Pharm, Dept Med Chem, Sari 48175, Iran

[3] Kerman Univ Med Sci, Fac Pharm, Kerman 76351, Iran

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 20期

基金：

美国国家科学基金会;

关键词：

bromothiophene; quinolone; oxime derivative; antibacterial activity;

D O I：

10.1016/j.bmcl.2005.07.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[2-(5-bromothiophen-2-yl)-2-oximinoethyl]derivatives of piperazinyl quinolones were synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. Some of these derivatives exhibit comparable or better activity against Gram-positive bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis, than ciprofloxacin, norfloxacin and enoxacine as reference drugs. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4536 / 4539

页数：4

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